In vitro, modafinil continues to be demonstrated to bind weakly but selectively for the dopamine transporter (Mignot et al 1994; Nishino et al 1998; Madras et al 2006) and, to a lesser extent, the norepinephrine transporter (Madras et al 2006). Wake-endorsing concentrations of modafinil increased extracellular levels of monoamines, including norepi

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